青春期激素增加α4βδGabaA受体的海马表达

  • A+
所属分类:疗效
摘要

Ca1海马表达α4βΔGabaa受体(GABARS)在女性小鼠的发作时增加,效果依赖于……

青春期激素增加α4βδGabaA受体的海马表达

普及塔尔E2是CA1海马中峰GABARα4和δ表达所必需的。

可以通过阻断THP合成预先触发α4和δ表达。

e2和THP取出在成人海马中产生峰值α4和δ表达。

e2增加α4和δ表达通过雌激素受体-α(ER-α)。

摘要

α4βδgabaa受体(GABAR)的Hippodal表达在女鼠雌性小鼠的雌性发作时增加依赖于此时发生的神经活体THP(3α-OH-5α-PEALAN-20-ONE)的海马水平的下降。本研究进一步表征了α4βδ表达的机制,体内评估。封锁青春期水平17β-雌二醇(E2)(Formestane,0.5mg / kg,IP 3d)降低α4和δ表达75-80%(p

缩写

3α-HSD3α-羟类肟衍生的神经营养的Factore217β -stradioler-αe2受体-αfin非非那甲甲醛蛋白质蛋白-Gabaa Acceptorgapdhglyceraldeded 3-磷酸脱氢酶Ici 182,780(即,富勒顿)PkcProtein激酶CPNDPost-NatalDaythP3α-OH-5α-Pregnan-20-One(allopregnanolone)Trkbtropomyosin受体激酶BVGCCoMyoSin受体激酶BVGCCoMyoSin受体激酶BVGCCV电压门钙通道

关键词< 0.05) in CA1 hippocampus of female mice, assessed using Western blot techniques. Conversely, E2 administration increased α4 and δ expression by 50–100% in adults, an effect enhanced by more than 2-fold by concomitant administration of the 5α-reductase blocker 非那雄胺 (50 mg/kg, i.p., 3d, P < 0.05), suggesting that both declining THP levels and increasing E2 levels before puberty trigger α4βδ expression. This effect was blocked by ICI 182,780 (20 mg/kg, s.c., 3 d), a selective blocker of E2 receptor-α (ER-α). These results suggest that both the rise in circulating levels of E2 and the decline in hippocampal THP levels at the onset of puberty trigger maximal levels of α4βδ expression in the CA1 hippocampus.

allopregnanolonalpha-4deltaestradiolgabaa actorca1 hippocampus1

现代地址:Regeneron Pharmaceuticals,777个老锯河河道,塔里敦,NY 10591。

查看全文

药道药道直邮药房 -

提供源头正品经济,权威渠道,品质保障。

  • 微信咨询
  • 这是我的微信扫一扫
  • weinxin
  • WhatsApp 沟通
  • 手机扫一扫二维码
  • weinxin

发表评论

:?: :razz: :sad: :evil: :!: :smile: :oops: :grin: :eek: :shock: :???: :cool: :lol: :mad: :twisted: :roll: :wink: :idea: :arrow: :neutral: :cry: :mrgreen: