新外用抗雄激素制剂可以在移植到小鼠中的人秃顶头皮刺激毛发的生长

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所属分类:疗效
摘要

这项研究的目的是测试的外用制剂的能力,非那雄胺和氟他胺再扩大在男性型BA毛囊…

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新外用抗雄激素制剂可以在移植到小鼠中的人秃顶头皮刺激毛发的生长

摘要

本研究的目的是测试的局部制剂的能力非那雄胺和氟他胺以重新放大毛囊男性秃顶。这是通过人的头皮的皮肤移植物移植的实验模型到SCID小鼠进行评价。了比较的毛发的生长阶段的含有每接枝,长度,轴的直径的平均值的毛发而言非那雄胺和氟他胺,和媒介物制剂的配方,和结构之间进行比较。氟他胺和非那雄胺有显著更高的效果( P <0.05) than the placebo in all the tested parameters, but flutamide demonstrated more hair per graft and longer hair shafts than 非那雄胺 ( P <0.05). The number of hairs per graft for flutamide and 非那雄胺 groups were 1.22±0.47 and 0.88±0.95 hairs/0.5 mm2 graft, respectively, versus 0.35±0.6 hairs/graft for vehicle-treated graft. Similarly, hair lengths for flutamide and 非那雄胺 were 5.82±0.50 and 4.50±0.32 mm, respectively, versus 2.83±0.18 mm for the vehicle-treated grafts. An in vitro diffusion study of flutamide gel using hairless mouse skin demonstrated the beneficial effect of the vehicle composition in comparison with a hydroalcoholic solution or a gel containing no penetration enhancer. It is therefore suggested that this topical composition containing flutamide or 非那雄胺 may effectively result in regression of male-pattern baldness.

关键词

雄激素alopeciaFlutamideFinasterideTopical药物deliverySkin permeationMice
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