睾酮在调节去势大鼠精囊囊性纤维化跨膜调节,腺苷酸环化酶,和cAMP水平

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所属分类:疗效
摘要

氯化物分泌物(CL – ) – 和碳酸氢盐(HCO3 – ) – 富液由精囊可能涉及囊性纤维化跨膜调节因子(CFTR),…

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睾酮在调节去势大鼠精囊囊性纤维化跨膜调节,腺苷酸环化酶,和cAMP水平

摘要

氯化的分泌物(CL - ) - 和碳酸氢盐(HCO 3 - ) - 由精囊富氧流体可能涉及囊性纤维化跨膜调节因子(CFTR),其活性可通过cAMP的刺激从涉及腺苷酸环化酶(AC)反应生成的。在这项研究中,我们在睾丸激素的影响下,精囊调查CFTR,交流,和cAMP的水平。睾丸成年雄性大鼠接受7天的治疗与睾酮的125或250微克/ kg /天用或不用氟他胺或非那雄胺。在治疗结束时,处死动物并收集用于通过Western印迹CFTR和AC蛋白质表达水平的分析精囊。被immunohistochemistr观察CFTR和AC在精囊中分布年。在精囊匀浆的cAMP水平和二氢通过ELISA测量。囊性纤维化跨膜调节,AC和cAMP水平随剂量的睾酮升高(P < 0.05 compared to nontreated orchidectomized rats). Cystic fibrosis transmembrane regulator and AC were expressed at the apical membrane of the epithelium lining the seminal vesicle lumen with higher expression levels observed in testosterone-treated rats than in non-treated orchidectomized rats (P < 0.05). The inhibitory effects of flutamide or 非那雄胺 on these parameters were greater in 250 μg/kg/day testosterone-treated rats than their effects in 125 μg/kg/day testosterone-treated rats. Higher dihydrotestosterone levels were observed in seminal vesicle homogenates after treatment with 250 μg/kg/day than with 125 μg/kg/day of testosterone (P < 0.05). Increased levels of CFTR, AC, and cAMP in seminal vesicles might contribute toward an increase in Cl− and HCO3− concentrations in the seminal fluid as reported under testosterone influence.

关键词

精囊炎vesicleTestosteroneCystic纤维化跨膜regulatorAdenylate cyclasecAMPView全文
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