的影响的抗雄激素非那雄胺对雄激素代谢的人牙龈成纤维细胞雌二醇的调节动作

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所属分类:疗效
摘要

在生物活性雄激素5α-二氢睾酮(DHT)的形成雄激素基板结果5α-还原,而17β-hydroxysteroi …

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的影响的抗雄激素非那雄胺对雄激素代谢的人牙龈成纤维细胞雌二醇的调节动作

摘要

中的生物活性的雄激素5α-二氢睾酮(DHT)的形成雄激素基板结果5α-还原,而17β羟基类固醇脱氢酶metabolises雄激素底物4-雄烯二酮或睾酮。这里的目的是研究的效果抗雄激素非那雄胺对5α-减少雄激素由人牙龈成纤维细胞(HGF)和雌二醇 - 17β其调制。 HGF的重复培养物温育[14 C]睾甾酮/ [14 C] 4-雄烯二酮的Eagle极限必需培养基( n的 = 6)中的雌二醇-17β(O)或非那雄存在或不存在胺(F; 0.1-3微克/毫升)处理24小时。类固醇的代谢产物进行分析,并使用放射性同位素扫描仪量化。与[14 C]睾甾酮为底物,雌甾 P n的 = 6; <0.01). In contrast, 非那雄胺 inhibited this activity by 61% ( P n的[123 adiol由63%( n的<0.01). The combination of O+F produced 43% less inhibition than 非那雄胺 alone ( = 6刺激DHT的形成] = 6; P n的<0.01). There were 200–300% increases in the formation of 4-androstenedione in response to O and F, being less pronounced in combination. Oestradiol stimulated the formation of DHT from [14C]4-androstenedione by 300–600% and 非那雄胺 reduced the yield of DHT by 40–64%; there was less inhibition in combination with O. There were 300–700% increases in the formation of testosterone in response to F and O alone and in combination ( = 6; P <0.01). Oestradiol-induced stimulation of 5α-reductase activity on androgen substrates by HGF is suggestive of hormone modulatory mechanisms in the healing periodontium of both sexes. Its inhibition by 非那雄胺 is suggestive of type 2 isoenzyme activity, confirming target-tissue functions in the gingiva.

关键词

OestrogenAnti-androgen5α还原酶表达

缩写123 ] DHT,5α-dihydrotestosteroneMEM,最小必需培养基

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